Novel aminopyridine derivatives having aurora a selective inhibitory action

具有Aurora A选择性抑制作用的新型氨基吡啶衍生物

Abstract

The present invention relates to a compound of Formula (I): wherein: n is 0 or 1; X is O or CH2; R1 is H or C1-2 alkyl; R2 is H or C1-3 alkyl; R3 and R4 are each independently H or C1-2 alkyl, where the alkyl may be substituted with one to three of the same or different substituents selected from R10 R5 is H or OCH3; R10 is F or Cl; or a pharmaceutically acceptable salt or ester thereof.
本发明涉及式(I)的化合物或其药学上可接受的盐或酯:其中:n为0或1;X为O或CH2;R1为H或C1-2烷基;R2为H或C1-3烷基;R3和R4各自独立为H或C1-2烷基,其中烷基可被一至三个相同或不同的选自R10的取代基取代;R5为H或OCH3;和R10为F或Cl。

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