Novel aminopyridine derivatives having aurora a selective inhibitory action

具有Aurora A选择性抑制作用的新型氨基吡啶衍生物


The present invention relates to a compound of Formula (I): wherein: n is 0 or 1; X is O or CH2; R1 is H or C1-2 alkyl; R2 is H or C1-3 alkyl; R3 and R4 are each independently H or C1-2 alkyl, where the alkyl may be substituted with one to three of the same or different substituents selected from R10 R5 is H or OCH3; R10 is F or Cl; or a pharmaceutically acceptable salt or ester thereof.




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Patent Citations (4)

    Publication numberPublication dateAssigneeTitle
    CN-101103017-AJanuary 09, 2008万有制药株式会社具有Aurora-A选择性抑制作用的新型氨基吡啶衍生物
    CN-1440410-ASeptember 03, 2003艾博特公司二氮杂二环中枢神经系统活性剂
    US-2007185111-A1August 09, 2007Cee Victor J, Deak Holly L, Bingfan Du, Geuns-Meyer Stephanie D, Hodous Brian L, Nguyen Hanh N, Olivieri Philip R, Patel Vinod F, Karina Romero, Laurie SchenkelAurora kinase modulators and method of use
    US-2007270444-A1November 22, 2007David Bebbington, Hayley Binch, Ronald Knegtel, Julian Golec, Sanjay Patel, Jean-Damien Charrier, David Kay, Robert Davies, Pan Li, Marion Wannamaker, Cornelia Forster, Albert PiercePyrazole compounds useful as protein kinase inhibitors

NO-Patent Citations (1)

    王晓霞等: "有丝分裂激酶Aurora-A 的功能及其与肿瘤发生的关系", 《国际遗传学杂志》, vol. 29, no. 2, 15 April 2006 (2006-04-15), pages 123 - 126

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    Publication numberPublication dateAssigneeTitle